Royal Air Force Typhoon jets have joined forces with French aircraft in a joint strike on an hidden munitions depot in Syrian territory used by the IS group, according to the UK's MoD.
The facility, identified by intelligence, was believed to be storing arms and explosives, the statement said, and was situated in mountainous terrain just north of Palmyra in Syria's central region.
"The RAF jets utilized Paveway IV guided bombs to hit a several approach shafts providing entry to the site... initial indications are that the strike was effective," the ministry announced.
There was no sign of any civilian casualties in the attack on Saturday evening and each participating jet returned to base without incident, the MoD added.
The Typhoon fighters were supported by a Voyager tanker plane.
Daesh - also known as Daesh - imposed jihadist rule over large swathes of Syria and Iraq until 2019.
"This operation underscores our UK leadership, and resolve to stand shoulder to shoulder with allied nations, to stamp out any re-emergence of IS and their harmful and extremist ideologies in the Middle East," UK Defence Secretary the minister remarked.
UK warplanes have conducted surveillance missions over Syria to "deter any efforts to regroup" of IS subsequent to its military defeat at the Baghuz confrontation in 2019, the MoD reported.
"I extend gratitude to the personnel of our armed forces involved in this operation for their professionalism and their courage," Healey commented. "They were part of thousands of British personnel deployed over Christmas and New Year. This operation, to eliminate terrorist threats who threaten our way of life, highlights how our armed forces are ready to step up, continuously, ensuring Britain's security within its borders and influential overseas."
During December, the US military conducted what it described as a "major assault" against IS targets in the country, subsequent to an attack killed two US troops and a civilian interpreter in Palmyra.
The United Nations estimates IS still maintains roughly 5-7 thousand fighters in Iraq and Syria.